CYPLEXINOL® – NATURE'S BMP COMPLEX
Cyplexinol® – Nature’s BMP complex, represents a quantum leap in cellular nutrition supplements for bone and cartilage tissue rebuilding. Cyplexinol® is the first and only, patented, oral, growth-factor complex which supports the body’s natural ability to grow new, healthy bone and cartilage tissue – something no other ingredient can offer.
Cyplexinol® is a natural growth-factor complex supporting the body’s ability to:

Grow healthy new bone tissue to strengthen bones naturally

Grow healthy new cartilage and connective tissue

Replenish the Gut lining and improve digestive health

Properly respond to inflammation
HOW IT WORKS
Cyplexinol® is a growth-factor complex, containing proteins and peptides known as bone morphogenetic proteins (BMP), the only natural proteins known to turn on mesenchymal stem cells, differentiating them into osteoblast and chondrocytes for de novo bone and cartilage tissue growth.

Since the 1960s, when this complex was first discovered by the late Dr. Marshall Urist, an orthopedic surgeon and researcher, BMPs and BMP-complexes have been used by millions of people to regenerate bone and cartilage tissue post-operatively—ushering in the field of osteobiologics and becoming the gold standard in spinal fusion and other orthopedic surgeries.
In the early 2000s, a group of leaders from the orthopedic spine industry established ZyCal Bioceuticals Healthcare Company, Inc. and established the manufacturing of Cyplexinol®, the first oral BMP-complex supporting healthy bones and joints. This complex is ideal for people who want to know how to strengthen bone density and cartilage tissue naturally.
BMPs in our body, naturally turn on mesenchymal stem cells (MSCs) to activate and differentiate them into osteoblasts in the bone and chondrocytes in the joints, which in turn produce new bone and cartilage tissue.

In the bone, dense and robust bone tissue is the essential “framework” or matrix needed for calcium and other minerals can to bind to for improved bone strength. Without the bone tissue, calcium has nothing to bind to and our bones become porous and weak. Thus, healthy bone starts with adequate levels of BMPs to activate the “cellular machinery” in our body. New research now shows that women loss up to 43% of at least one of these critical BMPs or signaling proteins from age 20 to 50, thus challenging our understanding of poor bone health in post-menopausal women.
In joints, once the MSCs are activated in the synovial fluid, the new chondrocytes migrate to the hyaline cartilage where they absorb nutrients or basic building blocks, such as glucosamine, chondroitin, and MSM – methylsulfonylmethane. These building blocks are then “stitched” together into key components of cartilage known as proteoglycans which are specialized glycosaminoglycans that are essential to keeping our joints healthy.
Recent research published in the Journal of Arthritis Research and Therapy correlated the decline of BMP levels in the joints of people with poor joint health, not the amount of basic building blocks they consume. Thus, healthy joints and strong cartilage tissue starts with adequate levels of BMPs to activate the “cellular machinery” in our joints.

Stem-Cell Activation Testing
Cyplexinol® is batch tested, by an independent laboratory confirming that each batch of Cyplexinol® turns on stem cells and grows de novo bone and cartilage tissue. This testing, the gold standard for orthopedic surgical companies, is performed in a live animal model, requires 45-80 days and confirms via histology, the growth of new bone and cartilage tissue. No other nutritional ingredient or supplement for bone and cartilage regenerative processes uses this testing, nor can pass this testing, putting Cyplexinol® on a level unlike traditional supplements for bone and joint health.
*These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.